HPV and Cervical Cancer Screening Medical Guidelines

HPV cotesting is emerging as the new standard of care and is acknowledged in clinical guidelines developed by major medical organizations, including the American Congress of Obstetricians and Gynecologists (ACOG), American Cancer Society (ACS), Association of Reproductive Health Professionals (ARHP), and American Society for Colposcopy and Cervical Pathology (ASCCP). Standard of Care is not set by any one individual guideline, but by the consensus of evidence and endorsement across the medical community. Today, with the body of clinical evidence supporting HPV testing, more than 10 leading medical organizations recommend HPV testing together with the Pap for women age 30 and older in their published guidelines:

American College of Obstetricians and Gynecologists (ACOG)

  • 2009: ACOG Practice Bulletin No. 109: “Cervical Cytology Screening” (guideline & OBG Management article)
  • 2005: ACOG Practice Bulletin No. 66, "Management of Abnormal Cervical Cytology and Histology: Clinical Management Guidelines for Obstetrician-Gynecologists."
  • 2005: ACOG Practice Bulletin No. 61, "Human Papillomavirus. Clinical Management Guidelines for Obstetrician-Gynecologists." (abstract)
  • 2003: ACOG Practice Bulletin No. 45, "Cervical Cytology Screening." Clinical Management Guidelines for Obstetrician-Gynecologists." (abstract)


ASCCP, National Cancer Institute (NCI) and American Cancer Society (ACS) - Consensus Guidelines

  • 2007: Wright, T. et al. 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests. Journal of Lower Genital Tract Disease. 11(4):201-222, October 2007. (guideline)
  • 2004: Wright, T. et al. Interim Guidance for the Use of HPV DNA Testing as an Adjunct to Cervical Cytology for Screening. Obstet and Gynecol, 103:304–9; February 2004. (abstract)

American Cancer Society

  • 2010: American Cancer Society Guidelines for the Early Detection of Cancer, www.cancer.org (guideline)
  • 2006: American Cancer Society Guidelines for the Early Detection of Cancer; CA Cancer J Clin 2006; 56:11-25 (guideline)

American Society for Colposcopy and Cervical Pathology (ASCCP)

  • 2009: ASCCP HPV Genotyping Clinical Update. (guideline)

American Association of Family Physicians (AAFP)

  • 2009: Apgar, B. et al. Update on ASCCP Consensus Guidelines for Abnormal Cervical Screening Tests and Cervical Histology. Am Fam Phy 80: 147-155. July 2009 (guideline)


Association of Reproductive Health Professionals (ARHP)

  • 2009: Managing HPV: A New Era in Patient Care - Screening for HPV-Related Cancer: HPV DNA Testing, Clinical Proceedings of the Association of Reproductive Health Professionals, June 2009. (guideline)
  • 2004: Periodic Well-Woman Visit: Individualized Contraceptive Care, Clinical Proceedings of the Association of Reproductive Health Professionals, May 2004. (guideline)

American Medical Women’s Association:


Centers for Disease Control and Prevention (CDC)

  • 2010: Sexually Transmitted Diseases Treatment Guidelines, 2010 Morbidity and Mortality Weekly Report (guideline)

National Association of Nurse Practitioners in Women’s Health

  • 2007: NPWH Guidelines for Cervical Cancer Screening: A Preview. www.np wh.org; January 2007 (guideline)

Society of Gynecologic Oncologists

  • 2009: Statement Regarding the Role of HPV Testing and HPV Typing in Cervical Cancer Prevention and Detection (statement)